By my count, there have been six major episodes in modern times in which Muslims rioted and killed in protest to some Western-based person making comments about Islam:
1989 – Salman Rushdie publishes his novel, The Satanic Verses.
1997 – The U.S. Supreme Court refuses to remove a 1930s frieze showing Muhammad as lawgiver.
2002 – The American evangelical leader Jerry Falwell calls Muhammad a "terrorist."
2005 – An incorrect story in Newsweek, reporting that American interrogators at Guantánamo Bay, "in an attempt to rattle suspects, flushed a Qur'an down a toilet."
February 2006 – The Danish newspaper Jyllands-Posten publishes twelve cartoons of Muhammad.
September 2006 – Pope Benedict XVI quotes a Byzantine emperor's views that what is new in Islam is "evil and inhuman."
Every one of these cases shares one particular feature: the persons who set off the ruckus had little to no idea that their views would lead to riots and deaths. Muslim disapproval, yes, not upheaval.