THE STUDY
"Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration" by Irving Kirsch et al., published online on February 26 in PLoS Medicine.

THE QUESTION
Irving Kirsch no longer sends patients to seek out antidepressants. "As a clinical psychologist," he says, "I used to refer patients to colleagues who were psychiatrists to get these medications." But his research over the years has soured him on the drugs, suggesting they work only marginally better in the average patient than a placebo pill. Kirsch recently analyzed the numbers behind a multitude of studies to answer the question: Do antidepressants work?