It's a video mashup of Will Smith talking about the "keys to success in life": running and reading. I totally agree. Over the years I've had the privilege of speaking about entrepreneurship several times at Tufts, Babson and a few other schools. My shtick includes a not-so-eloquent version of this speech.
Running is a metaphor for hard work. As Will says, when you run you learn to defeat that inner voice that says "I'm tired" or "quit now." I love the bit where Will says, "I knew I had to work hard...when other people where sleeping, I was working; when other people were eating, I was working." He summarizes, "the person who works the hardest wins."